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Dr, Jesús Porta-Etessam

Servicio de Neurología
Universidad Complutense
Hospital Clínico San Carlos de 
Madrid

Instituto de Neurociencias Aplicadas

C/ La granja, 8. Madrid

Consulta 5.5

Citaciones: 91 299 12 99

Redes sociales :

Noticias destacadas

Neurología

Alucinaciones auditivas en neurología cognitiva
A. Robles Bayón, M.G. Tirapu de Sagrario, F. Gude Sampedro Neurologia 2017;32:345-54 Resumen - Texto completo - PDF


Funciones ejecutivas y lenguaje en subtipos de niños con trastorno específico del lenguaje
V. Acosta Rodríguez, G.M. Ramírez Santana, S. Hernández Expósito Neurologia 2017;32:355-62 Resumen - Texto completo - PDF


Sleep architecture and the risk of incident dementia in the community
Objective: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). Methods: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male). Stages of sleep were quantified using home-based polysomnography. Participants were followed for a maximum of 19 years for incident dementia (mean follow-up 12 ± 5 years). Results: We observed 32 cases of incident dementia; 24 were consistent with Alzheimer disease dementia. After adjustments for age and sex, lower REM sleep percentage and longer REM sleep latency were both associated with a higher risk of incident dementia. Each percentage reduction in REM sleep was associated with approximately a 9% increase in the risk of incident dementia (hazard ratio 0.91; 95% confidence interval 0.86, 0.97). The magnitude of association between REM sleep percentage and dementia was similar following adjustments for multiple covariates including vascular risk factors, depressive symptoms, and medication use, following exclusions for persons with mild cognitive impairment at baseline and following exclusions for early converters to dementia. Stages of non-REM sleep were not associated with dementia risk. Conclusions: Despite contemporary interest in slow-wave sleep and dementia pathology, our findings implicate REM sleep mechanisms as predictors of clinical dementia.
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Can immune reprogramming with alemtuzumab induce permanent remission in multiple sclerosis?
Disease-modifying therapies (DMTs) for multiple sclerosis (MS) have developed tremendously over the last 2 decades. Currently, more than 16 different products targeting various immunologic components have been approved for MS treatment in several countries.
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Dr Jesús Porta-Etessam. Madrid